The Effect of Chronic Intoxication with 2-Chloroethanol on Immune Responses, Function of Th1 and Th2 Lymphocytes and Blood Cytokine Concentrations

Submit Manuscript | http://medcraveonline.com compound of general toxic effect; colorless viscous liquid with a weak ether odor; Is readily soluble in water, ethanol, acetone, 1,2-dichloroethane, chloroform. It is used as a solvent for inorganic salts, in organic synthesis (dissolves acetyl cellulose). Used to produce ethylene oxide, thiodiglycol, some dyes, pesticides and pharmaceuticals [1-3]. In emergency situations, violation of safety precautions CE can induce inhalation, oral poisoning, easily penetrates through skin. After intoxication of CE are amazed the central nervous system, cardiovascular system, kidneys, liver and other organs [1-4]. There are reasons to believe that CE metabolites can cause mutagenic, carcinogenic, and teratogenic and immunotoxic effects [3]. Dysfunctions of immune system, synthesis of lymphocytes and other blood cells of cytokines with chronic intoxication of CE with purpose of targeted correction of immune homeostasis for prevention of infectious complications and disease have not been studied [1-6]. The aim of the study was to assess the chronic effect of CE (60 days, daily subcutaneously 0.05 LD50) on immune responses, the function of Th1 and Th2 lymphocytes, as well as on the content of IFN-γ, interleukins IL2, IL-4, pro-inflammatory (TNF-α, IL-6) and anti-inflammatory cytokines (IL-10, IL-13).